Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice. [electronic resource]
Producer: 20170822Description: 367-371 p. digitalISSN:- 1476-4687
- Amyotrophic Lateral Sclerosis -- genetics
- Animals
- Ataxin-2 -- deficiency
- Central Nervous System -- metabolism
- Cytoplasmic Granules -- metabolism
- DNA-Binding Proteins -- chemistry
- Disease Progression
- Female
- Gene Knockdown Techniques
- Humans
- Longevity
- Male
- Mice
- Mice, Knockout
- Mice, Transgenic
- Motor Skills -- physiology
- Oligonucleotides, Antisense -- administration & dosage
- Protein Aggregation, Pathological -- genetics
- Stress, Physiological
- Survival Analysis
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Publication Type: Journal Article
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