Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells. [electronic resource]
Producer: 20181112Description: 44841 p. digitalISSN:- 2045-2322
- Alkyl and Aryl Transferases -- metabolism
- Apoptosis -- drug effects
- Cell Death -- drug effects
- Cell Line, Tumor
- Cell Membrane -- metabolism
- Cholesterol -- metabolism
- Dose-Response Relationship, Drug
- Farnesyltranstransferase -- metabolism
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacology
- Metabolic Networks and Pathways -- drug effects
- Mevalonic Acid -- metabolism
- Protein Transport
- Signal Transduction -- drug effects
- Simvastatin -- pharmacology
- Terpenes
- rho GTP-Binding Proteins -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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