Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells.

Alizadeh, Javad

Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells. [electronic resource] - Scientific reports 03 2017 - 44841 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

2045-2322

10.1038/srep44841 doi


Alkyl and Aryl Transferases--metabolism
Apoptosis--drug effects
Cell Death--drug effects
Cell Line, Tumor
Cell Membrane--metabolism
Cholesterol--metabolism
Dose-Response Relationship, Drug
Farnesyltranstransferase--metabolism
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors--pharmacology
Metabolic Networks and Pathways--drug effects
Mevalonic Acid--metabolism
Protein Transport
Signal Transduction--drug effects
Simvastatin--pharmacology
Terpenes
rho GTP-Binding Proteins--metabolism