Identification of mTOR as a primary resistance factor of the IAP antagonist AT406 in hepatocellular carcinoma cells. [electronic resource]
Producer: 20180222Description: 9466-9475 p. digitalISSN:- 1949-2553
- Acetates -- pharmacology
- Animals
- Antineoplastic Agents -- pharmacology
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Apoptosis -- drug effects
- Azocines -- pharmacology
- Benzhydryl Compounds -- pharmacology
- Benzopyrans -- pharmacology
- Carcinoma, Hepatocellular -- drug therapy
- Dose-Response Relationship, Drug
- Drug Resistance, Neoplasm -- drug effects
- Female
- Hep G2 Cells
- Humans
- Imidazoles -- pharmacology
- Inhibitor of Apoptosis Proteins -- antagonists & inhibitors
- Liver Neoplasms -- drug therapy
- Mice, Nude
- Mutation
- Myeloid Cell Leukemia Sequence 1 Protein -- genetics
- Protein Kinase Inhibitors -- pharmacology
- Protein Stability
- Proteolysis
- RNA Interference
- Ribosomal Protein S6 Kinases, 70-kDa -- genetics
- Signal Transduction -- drug effects
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
- Time Factors
- Transfection
- Triazines -- pharmacology
- Tumor Burden -- drug effects
- Ubiquitin-Protein Ligases -- antagonists & inhibitors
- X-Linked Inhibitor of Apoptosis Protein -- antagonists & inhibitors
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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