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Zhen, Mao-Chuan

Identification of mTOR as a primary resistance factor of the IAP antagonist AT406 in hepatocellular carcinoma cells. [electronic resource] - Oncotarget Feb 2017 - 9466-9475 p. digital

Publication Type: Journal Article

ISSN: 1949-2553

Standard No.: 10.18632/oncotarget.14326 doi

Subjects--Topical Terms:
Acetates--pharmacology
Animals
Antineoplastic Agents--pharmacology
Antineoplastic Combined Chemotherapy Protocols--pharmacology
Apoptosis--drug effects
Azocines--pharmacology
Benzhydryl Compounds--pharmacology
Benzopyrans--pharmacology
Carcinoma, Hepatocellular--drug therapy
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm--drug effects
Female
Hep G2 Cells
Humans
Imidazoles--pharmacology
Inhibitor of Apoptosis Proteins--antagonists & inhibitors
Liver Neoplasms--drug therapy
Mice, Nude
Mutation
Myeloid Cell Leukemia Sequence 1 Protein--genetics
Protein Kinase Inhibitors--pharmacology
Protein Stability
Proteolysis
RNA Interference
Ribosomal Protein S6 Kinases, 70-kDa--genetics
Signal Transduction--drug effects
TOR Serine-Threonine Kinases--antagonists & inhibitors
Time Factors
Transfection
Triazines--pharmacology
Tumor Burden--drug effects
Ubiquitin-Protein Ligases--antagonists & inhibitors
X-Linked Inhibitor of Apoptosis Protein--antagonists & inhibitors
Xenograft Model Antitumor Assays