Low dose triptolide reverses chemoresistance in adult acute lymphoblastic leukemia cells via reactive oxygen species generation and DNA damage response disruption. [electronic resource]
Producer: 20180221Description: 85515-85528 p. digitalISSN:- 1949-2553
- Adolescent
- Adult
- Aged
- Animals
- Antimetabolites, Antineoplastic -- pharmacology
- Antineoplastic Agents, Alkylating -- pharmacology
- Apoptosis -- drug effects
- Caspase 9 -- metabolism
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Checkpoint Kinase 1 -- metabolism
- Checkpoint Kinase 2 -- metabolism
- Cytarabine -- pharmacology
- DNA Damage
- Diterpenes -- pharmacology
- Dose-Response Relationship, Drug
- Doxorubicin -- pharmacology
- Drug Resistance, Multiple -- drug effects
- Drug Resistance, Neoplasm -- drug effects
- Epoxy Compounds -- pharmacology
- Female
- Histones -- metabolism
- Humans
- Inhibitory Concentration 50
- Male
- Membrane Potential, Mitochondrial -- drug effects
- Mice, Inbred NOD
- Mice, SCID
- Middle Aged
- Oxidative Stress -- drug effects
- Phenanthrenes -- pharmacology
- Precursor Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy
- Reactive Oxygen Species -- metabolism
- Signal Transduction -- drug effects
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
- Young Adult
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Publication Type: Journal Article
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