Low dose triptolide reverses chemoresistance in adult acute lymphoblastic leukemia cells via reactive oxygen species generation and DNA damage response disruption.

Zhao, Haijun

Low dose triptolide reverses chemoresistance in adult acute lymphoblastic leukemia cells via reactive oxygen species generation and DNA damage response disruption. [electronic resource] - Oncotarget Dec 2016 - 85515-85528 p. digital

Publication Type: Journal Article

1949-2553

10.18632/oncotarget.13454 doi


Adolescent
Adult
Aged
Animals
Antimetabolites, Antineoplastic--pharmacology
Antineoplastic Agents, Alkylating--pharmacology
Apoptosis--drug effects
Caspase 9--metabolism
Cell Line, Tumor
Cell Proliferation--drug effects
Checkpoint Kinase 1--metabolism
Checkpoint Kinase 2--metabolism
Cytarabine--pharmacology
DNA Damage
Diterpenes--pharmacology
Dose-Response Relationship, Drug
Doxorubicin--pharmacology
Drug Resistance, Multiple--drug effects
Drug Resistance, Neoplasm--drug effects
Epoxy Compounds--pharmacology
Female
Histones--metabolism
Humans
Inhibitory Concentration 50
Male
Membrane Potential, Mitochondrial--drug effects
Mice, Inbred NOD
Mice, SCID
Middle Aged
Oxidative Stress--drug effects
Phenanthrenes--pharmacology
Precursor Cell Lymphoblastic Leukemia-Lymphoma--drug therapy
Reactive Oxygen Species--metabolism
Signal Transduction--drug effects
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
Young Adult