Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model. [electronic resource]
Producer: 20180221Description: 83071-83087 p. digitalISSN:- 1949-2553
- Alkaloids -- pharmacology
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Caspase 3 -- metabolism
- Cell Adhesion -- drug effects
- Cell Cycle Proteins -- metabolism
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- Colorectal Neoplasms -- drug therapy
- Cytoskeleton -- drug effects
- Dose-Response Relationship, Drug
- G1 Phase Cell Cycle Checkpoints -- drug effects
- Guanidine -- analogs & derivatives
- HT29 Cells
- Hep G2 Cells
- Humans
- Inhibitory Concentration 50
- MCF-7 Cells
- Membrane Potential, Mitochondrial -- drug effects
- Signal Transduction -- drug effects
- Spiro Compounds -- pharmacology
- Time Factors
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
- Zebrafish
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Publication Type: Journal Article
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