Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model.

Roel, María

Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model. [electronic resource] - Oncotarget Dec 2016 - 83071-83087 p. digital

Publication Type: Journal Article

1949-2553

10.18632/oncotarget.13068 doi


Alkaloids--pharmacology
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Caspase 3--metabolism
Cell Adhesion--drug effects
Cell Cycle Proteins--metabolism
Cell Proliferation--drug effects
Cell Survival--drug effects
Colorectal Neoplasms--drug therapy
Cytoskeleton--drug effects
Dose-Response Relationship, Drug
G1 Phase Cell Cycle Checkpoints--drug effects
Guanidine--analogs & derivatives
HT29 Cells
Hep G2 Cells
Humans
Inhibitory Concentration 50
MCF-7 Cells
Membrane Potential, Mitochondrial--drug effects
Signal Transduction--drug effects
Spiro Compounds--pharmacology
Time Factors
Tumor Burden--drug effects
Xenograft Model Antitumor Assays
Zebrafish