LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. [electronic resource]
Producer: 20170321Description: 390-395 p. digitalISSN:- 1476-4687
- AMP-Activated Protein Kinase Kinases
- AMP-Activated Protein Kinases
- Animals
- Cell Culture Techniques
- Cell Line, Tumor
- Cell Transformation, Neoplastic
- Chromatin -- genetics
- DNA (Cytosine-5-)-Methyltransferases -- metabolism
- DNA Methylation -- drug effects
- Enzyme Inhibitors -- pharmacology
- Epithelial Cells -- metabolism
- Gene Silencing
- Genes, Tumor Suppressor
- Glycine -- metabolism
- Glycolysis
- Humans
- Mice
- Pancreatic Ducts -- cytology
- Protein Serine-Threonine Kinases -- deficiency
- Proto-Oncogene Proteins p21(ras) -- genetics
- Retroelements -- genetics
- S-Adenosylmethionine -- metabolism
- Serine -- biosynthesis
- TOR Serine-Threonine Kinases -- metabolism
- Transaminases -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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