LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.

Kottakis, Filippos

LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. [electronic resource] - Nature 11 2016 - 390-395 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1476-4687

10.1038/nature20132 doi


AMP-Activated Protein Kinase Kinases
AMP-Activated Protein Kinases
Animals
Cell Culture Techniques
Cell Line, Tumor
Cell Transformation, Neoplastic
Chromatin--genetics
DNA (Cytosine-5-)-Methyltransferases--metabolism
DNA Methylation--drug effects
Enzyme Inhibitors--pharmacology
Epithelial Cells--metabolism
Gene Silencing
Genes, Tumor Suppressor
Glycine--metabolism
Glycolysis
Humans
Mice
Pancreatic Ducts--cytology
Protein Serine-Threonine Kinases--deficiency
Proto-Oncogene Proteins p21(ras)--genetics
Retroelements--genetics
S-Adenosylmethionine--metabolism
Serine--biosynthesis
TOR Serine-Threonine Kinases--metabolism
Transaminases--metabolism