Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer. [electronic resource]
Producer: 20170425Description: 2286-2296 p. digitalISSN:- 1476-5594
- Antineoplastic Agents -- therapeutic use
- Breast Neoplasms -- drug therapy
- CRISPR-Cas Systems
- Cell Proliferation -- drug effects
- Cyclin-Dependent Kinases -- antagonists & inhibitors
- Estrogen Antagonists -- pharmacology
- Estrogen Receptor alpha -- genetics
- Estrogens -- pharmacology
- Female
- Gene Knock-In Techniques
- Histones -- metabolism
- Humans
- MCF-7 Cells
- Mutation
- Phosphorylation
- Serine -- metabolism
- Tamoxifen -- analogs & derivatives
- Cyclin-Dependent Kinase-Activating Kinase
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Publication Type: Journal Article
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