Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer.

Harrod, A

Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer. [electronic resource] - Oncogene 04 2017 - 2286-2296 p. digital

Publication Type: Journal Article

1476-5594

10.1038/onc.2016.382 doi


Antineoplastic Agents--therapeutic use
Breast Neoplasms--drug therapy
CRISPR-Cas Systems
Cell Proliferation--drug effects
Cyclin-Dependent Kinases--antagonists & inhibitors
Estrogen Antagonists--pharmacology
Estrogen Receptor alpha--genetics
Estrogens--pharmacology
Female
Gene Knock-In Techniques
Histones--metabolism
Humans
MCF-7 Cells
Mutation
Phosphorylation
Serine--metabolism
Tamoxifen--analogs & derivatives
Cyclin-Dependent Kinase-Activating Kinase