BAY61-3606 potentiates the anti-tumor effects of TRAIL against colon cancer through up-regulating DR4 and down-regulating NF-κB. [electronic resource]
Producer: 20170808Description: 145-153 p. digitalISSN:- 1872-7980
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- metabolism
- Colonic Neoplasms -- drug therapy
- Drug Synergism
- HCT116 Cells
- Humans
- Male
- Mice, Inbred BALB C
- Mice, Nude
- Mutation
- NF-kappa B -- metabolism
- Niacinamide -- analogs & derivatives
- Proto-Oncogene Proteins p21(ras) -- genetics
- Pyrimidines -- pharmacology
- Receptors, TNF-Related Apoptosis-Inducing Ligand -- drug effects
- Signal Transduction -- drug effects
- TNF-Related Apoptosis-Inducing Ligand -- pharmacology
- Time Factors
- Transfection
- Tumor Burden -- drug effects
- Tumor Suppressor Protein p53 -- genetics
- Up-Regulation
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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