BAY61-3606 potentiates the anti-tumor effects of TRAIL against colon cancer through up-regulating DR4 and down-regulating NF-κB.

Du, Jipei

BAY61-3606 potentiates the anti-tumor effects of TRAIL against colon cancer through up-regulating DR4 and down-regulating NF-κB. [electronic resource] - Cancer letters 12 2016 - 145-153 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1872-7980

10.1016/j.canlet.2016.10.002 doi


Animals
Antineoplastic Combined Chemotherapy Protocols--pharmacology
Apoptosis--drug effects
Apoptosis Regulatory Proteins--metabolism
Colonic Neoplasms--drug therapy
Drug Synergism
HCT116 Cells
Humans
Male
Mice, Inbred BALB C
Mice, Nude
Mutation
NF-kappa B--metabolism
Niacinamide--analogs & derivatives
Proto-Oncogene Proteins p21(ras)--genetics
Pyrimidines--pharmacology
Receptors, TNF-Related Apoptosis-Inducing Ligand--drug effects
Signal Transduction--drug effects
TNF-Related Apoptosis-Inducing Ligand--pharmacology
Time Factors
Transfection
Tumor Burden--drug effects
Tumor Suppressor Protein p53--genetics
Up-Regulation
Xenograft Model Antitumor Assays