Quinacrine induces apoptosis in cancer cells by forming a functional bridge between TRAIL-DR5 complex and modulating the mitochondrial intrinsic cascade. [electronic resource]
Producer: 20180221Description: 248-267 p. digitalISSN:- 1949-2553
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Caspase 3 -- metabolism
- Caspase 8 -- metabolism
- Caspase 9 -- metabolism
- Cell Line, Tumor
- Cytochromes c -- metabolism
- Dose-Response Relationship, Drug
- Enzyme-Linked Immunosorbent Assay
- Fas-Associated Death Domain Protein -- metabolism
- Female
- Gene Knockdown Techniques
- Humans
- Immunohistochemistry
- Mice
- Mice, Inbred BALB C
- Mitochondria -- drug effects
- Molecular Dynamics Simulation
- Quinacrine -- pharmacology
- RNA Interference
- RNA, Small Interfering -- metabolism
- Reactive Oxygen Species -- metabolism
- Receptors, TNF-Related Apoptosis-Inducing Ligand -- agonists
- Signal Transduction -- drug effects
- TNF-Related Apoptosis-Inducing Ligand -- metabolism
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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