Quinacrine induces apoptosis in cancer cells by forming a functional bridge between TRAIL-DR5 complex and modulating the mitochondrial intrinsic cascade.

Das, Sarita

Quinacrine induces apoptosis in cancer cells by forming a functional bridge between TRAIL-DR5 complex and modulating the mitochondrial intrinsic cascade. [electronic resource] - Oncotarget Jan 2017 - 248-267 p. digital

Publication Type: Journal Article

1949-2553

10.18632/oncotarget.11335 doi


Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Caspase 3--metabolism
Caspase 8--metabolism
Caspase 9--metabolism
Cell Line, Tumor
Cytochromes c--metabolism
Dose-Response Relationship, Drug
Enzyme-Linked Immunosorbent Assay
Fas-Associated Death Domain Protein--metabolism
Female
Gene Knockdown Techniques
Humans
Immunohistochemistry
Mice
Mice, Inbred BALB C
Mitochondria--drug effects
Molecular Dynamics Simulation
Quinacrine--pharmacology
RNA Interference
RNA, Small Interfering--metabolism
Reactive Oxygen Species--metabolism
Receptors, TNF-Related Apoptosis-Inducing Ligand--agonists
Signal Transduction--drug effects
TNF-Related Apoptosis-Inducing Ligand--metabolism
Xenograft Model Antitumor Assays