The ATG16L1 risk allele associated with Crohn's disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines. [electronic resource]
Producer: 20171107Description: 352-360 p. digitalISSN:- 1935-3456
- Alleles
- Animals
- Autophagy -- genetics
- Autophagy-Related Proteins -- genetics
- Cell Membrane Structures -- pathology
- Cell Movement
- Cells, Cultured
- Colitis, Ulcerative -- drug therapy
- Crohn Disease -- drug therapy
- Cytoskeleton -- metabolism
- Dendritic Cells -- pathology
- Female
- Genetic Predisposition to Disease
- Humans
- Mercaptopurine -- therapeutic use
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Polymorphism, Genetic
- RNA, Small Interfering -- genetics
- Risk
- rac1 GTP-Binding Protein -- metabolism
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Publication Type: Journal Article
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