The ATG16L1 risk allele associated with Crohn's disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines.
Wildenberg, M E
The ATG16L1 risk allele associated with Crohn's disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines. [electronic resource] - Mucosal immunology 03 2017 - 352-360 p. digital
Publication Type: Journal Article
1935-3456
10.1038/mi.2016.65 doi
Alleles
Animals
Autophagy--genetics
Autophagy-Related Proteins--genetics
Cell Membrane Structures--pathology
Cell Movement
Cells, Cultured
Colitis, Ulcerative--drug therapy
Crohn Disease--drug therapy
Cytoskeleton--metabolism
Dendritic Cells--pathology
Female
Genetic Predisposition to Disease
Humans
Mercaptopurine--therapeutic use
Mice
Mice, Inbred C57BL
Mice, Knockout
Polymorphism, Genetic
RNA, Small Interfering--genetics
Risk
rac1 GTP-Binding Protein--metabolism
The ATG16L1 risk allele associated with Crohn's disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines. [electronic resource] - Mucosal immunology 03 2017 - 352-360 p. digital
Publication Type: Journal Article
1935-3456
10.1038/mi.2016.65 doi
Alleles
Animals
Autophagy--genetics
Autophagy-Related Proteins--genetics
Cell Membrane Structures--pathology
Cell Movement
Cells, Cultured
Colitis, Ulcerative--drug therapy
Crohn Disease--drug therapy
Cytoskeleton--metabolism
Dendritic Cells--pathology
Female
Genetic Predisposition to Disease
Humans
Mercaptopurine--therapeutic use
Mice
Mice, Inbred C57BL
Mice, Knockout
Polymorphism, Genetic
RNA, Small Interfering--genetics
Risk
rac1 GTP-Binding Protein--metabolism