Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK. [electronic resource]
Producer: 20170619Description: 3562-6 p. digitalISSN:- 1464-3405
- Administration, Oral
- Animals
- Antineoplastic Agents -- administration & dosage
- Benzamides -- administration & dosage
- Biological Availability
- Cell Cycle Proteins -- antagonists & inhibitors
- Cell Death -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Dose-Response Relationship, Drug
- Drug Discovery
- Drug Screening Assays, Antitumor
- Humans
- Mice
- Models, Molecular
- Molecular Structure
- Protein Kinase Inhibitors -- administration & dosage
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- Rats
- Structure-Activity Relationship
- Triazines -- administration & dosage
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Publication Type: Journal Article
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