Evaluation of Cytochrome P450 3A4-Mediated Drug-Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation. [electronic resource]
Producer: 20170911Description: 1435-1445 p. digitalISSN:- 1179-1926
- Administration, Oral
- Alkynes
- Area Under Curve
- Azetidines -- pharmacokinetics
- Benzoxazines -- pharmacology
- Computer Simulation
- Cyclopropanes
- Cytochrome P-450 CYP3A -- metabolism
- Cytochrome P-450 CYP3A Inducers -- pharmacology
- Cytochrome P-450 CYP3A Inhibitors -- pharmacology
- Diltiazem -- pharmacology
- Drug Interactions
- Erythromycin -- pharmacology
- Fluvoxamine -- pharmacology
- Humans
- Models, Biological
- Piperidines -- pharmacokinetics
- Retrospective Studies
- Rifampin -- pharmacology
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Publication Type: Journal Article
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