Evaluation of Cytochrome P450 3A4-Mediated Drug-Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation.

Budha, Nageshwar R

Evaluation of Cytochrome P450 3A4-Mediated Drug-Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation. [electronic resource] - Clinical pharmacokinetics 11 2016 - 1435-1445 p. digital

Publication Type: Journal Article

1179-1926

10.1007/s40262-016-0412-5 doi


Administration, Oral
Alkynes
Area Under Curve
Azetidines--pharmacokinetics
Benzoxazines--pharmacology
Computer Simulation
Cyclopropanes
Cytochrome P-450 CYP3A--metabolism
Cytochrome P-450 CYP3A Inducers--pharmacology
Cytochrome P-450 CYP3A Inhibitors--pharmacology
Diltiazem--pharmacology
Drug Interactions
Erythromycin--pharmacology
Fluvoxamine--pharmacology
Humans
Models, Biological
Piperidines--pharmacokinetics
Retrospective Studies
Rifampin--pharmacology