Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration.

Panarese, Joseph D

Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration. [electronic resource] - Bioorganic & medicinal chemistry letters 08 2016 - 3822-5 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1464-3405

10.1016/j.bmcl.2016.04.083 doi


Allosteric Regulation--drug effects
Animals
Central Nervous System--drug effects
Central Nervous System Agents--chemical synthesis
Dose-Response Relationship, Drug
Drug Discovery
Heterocyclic Compounds--chemical synthesis
Molecular Structure
Pyridines--chemical synthesis
Pyrroles--chemical synthesis
Rats
Receptor, Muscarinic M1--metabolism
Structure-Activity Relationship