SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-β1 via ROS/p38 MAPK/STAT3 pathway. [electronic resource]
Producer: 20180326Description: 25754 p. digitalISSN:- 2045-2322
- A549 Cells
- Animals
- Disease Models, Animal
- Early Growth Response Protein 1 -- metabolism
- Epithelial Cells -- metabolism
- Fibrosis
- Gene Silencing -- drug effects
- Glial Fibrillary Acidic Protein -- metabolism
- Humans
- Lung -- cytology
- Mice, Inbred BALB C
- Models, Biological
- NF-kappa B -- metabolism
- Papain -- pharmacology
- Promoter Regions, Genetic -- genetics
- RNA, Messenger -- genetics
- RNA, Small Interfering -- metabolism
- Reactive Oxygen Species -- metabolism
- Severe acute respiratory syndrome-related coronavirus -- enzymology
- STAT3 Transcription Factor -- metabolism
- Signal Transduction -- drug effects
- Sp1 Transcription Factor -- metabolism
- Thrombospondin 1 -- metabolism
- Transforming Growth Factor beta1 -- biosynthesis
- Up-Regulation -- drug effects
- Vimentin -- metabolism
- p38 Mitogen-Activated Protein Kinases -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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