SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-β1 via ROS/p38 MAPK/STAT3 pathway.

Li, Shih-Wein

SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-β1 via ROS/p38 MAPK/STAT3 pathway. [electronic resource] - Scientific reports 05 2016 - 25754 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2045-2322

10.1038/srep25754 doi


A549 Cells
Animals
Disease Models, Animal
Early Growth Response Protein 1--metabolism
Epithelial Cells--metabolism
Fibrosis
Gene Silencing--drug effects
Glial Fibrillary Acidic Protein--metabolism
Humans
Lung--cytology
Mice, Inbred BALB C
Models, Biological
NF-kappa B--metabolism
Papain--pharmacology
Promoter Regions, Genetic--genetics
RNA, Messenger--genetics
RNA, Small Interfering--metabolism
Reactive Oxygen Species--metabolism
Severe acute respiratory syndrome-related coronavirus--enzymology
STAT3 Transcription Factor--metabolism
Signal Transduction--drug effects
Sp1 Transcription Factor--metabolism
Thrombospondin 1--metabolism
Transforming Growth Factor beta1--biosynthesis
Up-Regulation--drug effects
Vimentin--metabolism
p38 Mitogen-Activated Protein Kinases--metabolism