Amelioration of ER stress by 4-phenylbutyric acid reduces chronic hypoxia induced cardiac damage and improves hypoxic tolerance through upregulation of HIF-1α. [electronic resource]
Producer: 20170605Description: 36-46 p. digitalISSN:- 1879-3649
- Altitude
- Animals
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- metabolism
- Chronic Disease
- Cytoprotection
- Disease Models, Animal
- Endoplasmic Reticulum Stress -- drug effects
- Hypertrophy, Right Ventricular -- metabolism
- Hypoxia -- drug therapy
- Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism
- Male
- Molecular Chaperones -- metabolism
- Myocardium -- metabolism
- Oxidative Stress -- drug effects
- Phenylbutyrates -- pharmacology
- Protein Carbonylation -- drug effects
- Proteolysis
- Rats, Sprague-Dawley
- Signal Transduction -- drug effects
- Time Factors
- Unfolded Protein Response -- drug effects
- Up-Regulation
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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