Amelioration of ER stress by 4-phenylbutyric acid reduces chronic hypoxia induced cardiac damage and improves hypoxic tolerance through upregulation of HIF-1α.

Jain, Kanika

Amelioration of ER stress by 4-phenylbutyric acid reduces chronic hypoxia induced cardiac damage and improves hypoxic tolerance through upregulation of HIF-1α. [electronic resource] - Vascular pharmacology 08 2016 - 36-46 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1879-3649

10.1016/j.vph.2016.03.004 doi


Altitude
Animals
Apoptosis--drug effects
Apoptosis Regulatory Proteins--metabolism
Chronic Disease
Cytoprotection
Disease Models, Animal
Endoplasmic Reticulum Stress--drug effects
Hypertrophy, Right Ventricular--metabolism
Hypoxia--drug therapy
Hypoxia-Inducible Factor 1, alpha Subunit--metabolism
Male
Molecular Chaperones--metabolism
Myocardium--metabolism
Oxidative Stress--drug effects
Phenylbutyrates--pharmacology
Protein Carbonylation--drug effects
Proteolysis
Rats, Sprague-Dawley
Signal Transduction--drug effects
Time Factors
Unfolded Protein Response--drug effects
Up-Regulation