Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation. [electronic resource]
Producer: 20161114Description: 313-9 p. digitalISSN:- 1476-5578
- Animals
- Antidepressive Agents -- pharmacology
- Cells, Cultured
- Cerebral Cortex -- cytology
- Cysteine -- analogs & derivatives
- Depression -- drug therapy
- Disease Models, Animal
- Embryo, Mammalian
- Exploratory Behavior -- drug effects
- Female
- Gene Expression Regulation -- drug effects
- HEK293 Cells
- Humans
- Ketamine -- pharmacology
- Male
- Mice, Inbred C57BL
- Mice, Knockout
- Monomeric GTP-Binding Proteins -- genetics
- N-Methylaspartate -- pharmacology
- Neurons -- drug effects
- Neuropeptides -- genetics
- Nitric Oxide -- genetics
- Nitric Oxide Synthase Type I -- deficiency
- Nitric Oxide Synthase Type II -- deficiency
- Pregnancy
- Proteolysis -- drug effects
- Ras Homolog Enriched in Brain Protein
- S-Nitrosothiols -- pharmacology
- Signal Transduction -- drug effects
- Swimming -- psychology
- TOR Serine-Threonine Kinases -- genetics
- Time Factors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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