Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation.

Harraz, M M

Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation. [electronic resource] - Molecular psychiatry Mar 2016 - 313-9 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1476-5578

10.1038/mp.2015.211 doi


Animals
Antidepressive Agents--pharmacology
Cells, Cultured
Cerebral Cortex--cytology
Cysteine--analogs & derivatives
Depression--drug therapy
Disease Models, Animal
Embryo, Mammalian
Exploratory Behavior--drug effects
Female
Gene Expression Regulation--drug effects
HEK293 Cells
Humans
Ketamine--pharmacology
Male
Mice, Inbred C57BL
Mice, Knockout
Monomeric GTP-Binding Proteins--genetics
N-Methylaspartate--pharmacology
Neurons--drug effects
Neuropeptides--genetics
Nitric Oxide--genetics
Nitric Oxide Synthase Type I--deficiency
Nitric Oxide Synthase Type II--deficiency
Pregnancy
Proteolysis--drug effects
Ras Homolog Enriched in Brain Protein
S-Nitrosothiols--pharmacology
Signal Transduction--drug effects
Swimming--psychology
TOR Serine-Threonine Kinases--genetics
Time Factors