M10, a caspase cleavage product of the hepatocyte growth factor receptor, interacts with Smad2 and demonstrates antifibrotic properties in vitro and in vivo. [electronic resource]
Producer: 20160802Description: 99-111 p. digitalISSN:- 1878-1810
- Amino Acid Sequence
- Animals
- Anti-Inflammatory Agents, Non-Steroidal -- pharmacology
- Caspase 3 -- metabolism
- Cell Survival -- drug effects
- Cells, Cultured
- Collagen -- metabolism
- Disease Models, Animal
- Fibroblasts -- drug effects
- Humans
- Lung -- cytology
- Male
- Mice, Inbred C57BL
- Molecular Sequence Data
- Peptide Fragments -- metabolism
- Proto-Oncogene Proteins c-met -- metabolism
- Pulmonary Fibrosis -- drug therapy
- Scleroderma, Systemic -- drug therapy
- Skin -- cytology
- Smad2 Protein -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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