Hyperactive ERK and persistent mTOR signaling characterize vemurafenib resistance in papillary thyroid cancer cells. [electronic resource]
Producer: 20170109Description: 8676-87 p. digitalISSN:- 1949-2553
- Apoptosis -- drug effects
- Blotting, Western
- Carcinoma, Papillary -- drug therapy
- Cell Proliferation -- drug effects
- Drug Resistance, Neoplasm
- Humans
- Immunoprecipitation
- Indoles -- pharmacology
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Mitogen-Activated Protein Kinase 3 -- metabolism
- Phosphorylation
- Signal Transduction -- drug effects
- Sulfonamides -- pharmacology
- TOR Serine-Threonine Kinases -- metabolism
- Thyroid Neoplasms -- drug therapy
- Tumor Cells, Cultured
- Vemurafenib
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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