Hyperactive ERK and persistent mTOR signaling characterize vemurafenib resistance in papillary thyroid cancer cells.

Hanly, Elyse K

Hyperactive ERK and persistent mTOR signaling characterize vemurafenib resistance in papillary thyroid cancer cells. [electronic resource] - Oncotarget Feb 2016 - 8676-87 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1949-2553

10.18632/oncotarget.6779 doi


Apoptosis--drug effects
Blotting, Western
Carcinoma, Papillary--drug therapy
Cell Proliferation--drug effects
Drug Resistance, Neoplasm
Humans
Immunoprecipitation
Indoles--pharmacology
Mitogen-Activated Protein Kinase 1--metabolism
Mitogen-Activated Protein Kinase 3--metabolism
Phosphorylation
Signal Transduction--drug effects
Sulfonamides--pharmacology
TOR Serine-Threonine Kinases--metabolism
Thyroid Neoplasms--drug therapy
Tumor Cells, Cultured
Vemurafenib