SKLB-677, an FLT3 and Wnt/β-catenin signaling inhibitor, displays potent activity in models of FLT3-driven AML. [electronic resource]
Producer: 20160915Description: 15646 p. digitalISSN:- 2045-2322
- Animals
- Animals, Genetically Modified
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- Drug Resistance, Neoplasm
- Female
- G1 Phase Cell Cycle Checkpoints -- drug effects
- Humans
- Isoxazoles -- pharmacology
- Leukemia, Myeloid, Acute -- drug therapy
- Mice
- Mice, Inbred NOD
- Mice, SCID
- Phenylurea Compounds -- chemistry
- Pyrazoles -- chemistry
- Pyrimidines -- chemistry
- Urea -- analogs & derivatives
- Wnt Proteins -- antagonists & inhibitors
- Wnt Signaling Pathway -- drug effects
- Zebrafish
- beta Catenin -- antagonists & inhibitors
- fms-Like Tyrosine Kinase 3 -- antagonists & inhibitors
No physical items for this record
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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