SKLB-677, an FLT3 and Wnt/β-catenin signaling inhibitor, displays potent activity in models of FLT3-driven AML.
Ma, Shuang
SKLB-677, an FLT3 and Wnt/β-catenin signaling inhibitor, displays potent activity in models of FLT3-driven AML. [electronic resource] - Scientific reports Oct 2015 - 15646 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2045-2322
10.1038/srep15646 doi
Animals
Animals, Genetically Modified
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Cell Survival--drug effects
Drug Resistance, Neoplasm
Female
G1 Phase Cell Cycle Checkpoints--drug effects
Humans
Isoxazoles--pharmacology
Leukemia, Myeloid, Acute--drug therapy
Mice
Mice, Inbred NOD
Mice, SCID
Phenylurea Compounds--chemistry
Pyrazoles--chemistry
Pyrimidines--chemistry
Urea--analogs & derivatives
Wnt Proteins--antagonists & inhibitors
Wnt Signaling Pathway--drug effects
Zebrafish
beta Catenin--antagonists & inhibitors
fms-Like Tyrosine Kinase 3--antagonists & inhibitors
SKLB-677, an FLT3 and Wnt/β-catenin signaling inhibitor, displays potent activity in models of FLT3-driven AML. [electronic resource] - Scientific reports Oct 2015 - 15646 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2045-2322
10.1038/srep15646 doi
Animals
Animals, Genetically Modified
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Cell Survival--drug effects
Drug Resistance, Neoplasm
Female
G1 Phase Cell Cycle Checkpoints--drug effects
Humans
Isoxazoles--pharmacology
Leukemia, Myeloid, Acute--drug therapy
Mice
Mice, Inbred NOD
Mice, SCID
Phenylurea Compounds--chemistry
Pyrazoles--chemistry
Pyrimidines--chemistry
Urea--analogs & derivatives
Wnt Proteins--antagonists & inhibitors
Wnt Signaling Pathway--drug effects
Zebrafish
beta Catenin--antagonists & inhibitors
fms-Like Tyrosine Kinase 3--antagonists & inhibitors