B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy. [electronic resource]
Producer: 20160823Description: 30939-56 p. digitalISSN:- 1949-2553
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Autophagy -- drug effects
- Blotting, Western
- Cell Cycle -- drug effects
- Cell Proliferation -- drug effects
- Curcumin -- analogs & derivatives
- Female
- Fluorescent Antibody Technique
- Humans
- Immunoenzyme Techniques
- Immunoprecipitation
- Membrane Potential, Mitochondrial -- drug effects
- Mitochondria -- drug effects
- RNA, Messenger -- genetics
- Reactive Oxygen Species -- metabolism
- Real-Time Polymerase Chain Reaction
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction -- drug effects
- Thioredoxin-Disulfide Reductase -- antagonists & inhibitors
- Tumor Cells, Cultured
- Uterine Cervical Neoplasms -- drug therapy
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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