B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy.
Shao, Fang-Yuan
B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy. [electronic resource] - Oncotarget Oct 2015 - 30939-56 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1949-2553
10.18632/oncotarget.5132 doi
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Autophagy--drug effects
Blotting, Western
Cell Cycle--drug effects
Cell Proliferation--drug effects
Curcumin--analogs & derivatives
Female
Fluorescent Antibody Technique
Humans
Immunoenzyme Techniques
Immunoprecipitation
Membrane Potential, Mitochondrial--drug effects
Mitochondria--drug effects
RNA, Messenger--genetics
Reactive Oxygen Species--metabolism
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction--drug effects
Thioredoxin-Disulfide Reductase--antagonists & inhibitors
Tumor Cells, Cultured
Uterine Cervical Neoplasms--drug therapy
B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy. [electronic resource] - Oncotarget Oct 2015 - 30939-56 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1949-2553
10.18632/oncotarget.5132 doi
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Autophagy--drug effects
Blotting, Western
Cell Cycle--drug effects
Cell Proliferation--drug effects
Curcumin--analogs & derivatives
Female
Fluorescent Antibody Technique
Humans
Immunoenzyme Techniques
Immunoprecipitation
Membrane Potential, Mitochondrial--drug effects
Mitochondria--drug effects
RNA, Messenger--genetics
Reactive Oxygen Species--metabolism
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction--drug effects
Thioredoxin-Disulfide Reductase--antagonists & inhibitors
Tumor Cells, Cultured
Uterine Cervical Neoplasms--drug therapy