A variant in 3'-untranslated region of KRAS compromises its interaction with hsa-let-7g and contributes to the development of lung cancer in patients with COPD. [electronic resource]
Producer: 20160425Description: 1641-9 p. digitalISSN:- 1178-2005
- 3' Untranslated Regions
- Aged
- Base Sequence
- Binding Sites
- Cell Line, Tumor
- Chi-Square Distribution
- Female
- Gene Expression Regulation, Neoplastic
- Gene Frequency
- Genes, Reporter
- Genetic Predisposition to Disease
- Humans
- Luciferases -- biosynthesis
- Lung Neoplasms -- genetics
- Male
- MicroRNAs -- genetics
- Middle Aged
- Molecular Sequence Data
- Odds Ratio
- Polymorphism, Single Nucleotide
- Proto-Oncogene Proteins p21(ras) -- genetics
- Pulmonary Disease, Chronic Obstructive -- complications
- RNA, Messenger -- genetics
- Risk Assessment
- Risk Factors
- Smoking -- adverse effects
- Transfection
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Publication Type: Journal Article
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