Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity. [electronic resource]
Producer: 20160614Description: 540-51 p. digitalISSN:- 1768-3254
- Antineoplastic Agents -- chemical synthesis
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- DNA Topoisomerases, Type I -- metabolism
- Dose-Response Relationship, Drug
- Drug Design
- Drug Screening Assays, Antitumor
- HEK293 Cells
- HeLa Cells
- Humans
- MCF-7 Cells
- Models, Molecular
- Molecular Structure
- Structure-Activity Relationship
- Thiohydantoins -- chemical synthesis
- Topoisomerase I Inhibitors -- chemical synthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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