Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity.
Majumdar, Papiya
Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity. [electronic resource] - European journal of medicinal chemistry Sep 2015 - 540-51 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1768-3254
10.1016/j.ejmech.2015.08.032 doi
Antineoplastic Agents--chemical synthesis
Cell Proliferation--drug effects
Cell Survival--drug effects
DNA Topoisomerases, Type I--metabolism
Dose-Response Relationship, Drug
Drug Design
Drug Screening Assays, Antitumor
HEK293 Cells
HeLa Cells
Humans
MCF-7 Cells
Models, Molecular
Molecular Structure
Structure-Activity Relationship
Thiohydantoins--chemical synthesis
Topoisomerase I Inhibitors--chemical synthesis
Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity. [electronic resource] - European journal of medicinal chemistry Sep 2015 - 540-51 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1768-3254
10.1016/j.ejmech.2015.08.032 doi
Antineoplastic Agents--chemical synthesis
Cell Proliferation--drug effects
Cell Survival--drug effects
DNA Topoisomerases, Type I--metabolism
Dose-Response Relationship, Drug
Drug Design
Drug Screening Assays, Antitumor
HEK293 Cells
HeLa Cells
Humans
MCF-7 Cells
Models, Molecular
Molecular Structure
Structure-Activity Relationship
Thiohydantoins--chemical synthesis
Topoisomerase I Inhibitors--chemical synthesis