Development of a physiologically based pharmacokinetic/pharmacodynamic model to identify mechanisms contributing to entacapone low bioavailability. [electronic resource]
Producer: 20161014Description: 587-602 p. digitalISSN:- 1099-081X
- Adult
- Animals
- Antiparkinson Agents -- blood
- Biological Availability
- Biotransformation
- Caco-2 Cells
- Catechol O-Methyltransferase Inhibitors -- blood
- Catechols -- blood
- Computational Biology
- Enterocytes -- metabolism
- Expert Systems
- Humans
- Intestinal Absorption
- Liver -- metabolism
- Male
- Metabolic Clearance Rate
- Models, Biological
- Nitriles -- blood
- Phosphorylation
- Prodrugs -- analysis
- Rats
- Solubility
- Tissue Distribution
No physical items for this record
Publication Type: Journal Article
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