Development of a physiologically based pharmacokinetic/pharmacodynamic model to identify mechanisms contributing to entacapone low bioavailability.

Alqahtani, Saeed

Development of a physiologically based pharmacokinetic/pharmacodynamic model to identify mechanisms contributing to entacapone low bioavailability. [electronic resource] - Biopharmaceutics & drug disposition Dec 2015 - 587-602 p. digital

Publication Type: Journal Article

1099-081X

10.1002/bdd.1986 doi


Adult
Animals
Antiparkinson Agents--blood
Biological Availability
Biotransformation
Caco-2 Cells
Catechol O-Methyltransferase Inhibitors--blood
Catechols--blood
Computational Biology
Enterocytes--metabolism
Expert Systems
Humans
Intestinal Absorption
Liver--metabolism
Male
Metabolic Clearance Rate
Models, Biological
Nitriles--blood
Phosphorylation
Prodrugs--analysis
Rats
Solubility
Tissue Distribution