Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation. [electronic resource]
Producer: 20160506Description: e0135083 p. digitalISSN:- 1932-6203
- Acetylcysteine -- pharmacology
- Animals
- Antineoplastic Agents -- toxicity
- Apoptosis -- drug effects
- Cell Line
- Cell Proliferation -- drug effects
- Cisplatin -- toxicity
- Citric Acid Cycle -- drug effects
- Dose-Response Relationship, Drug
- Epithelial Cells -- cytology
- Gene Expression Regulation
- Glycolysis -- drug effects
- Humans
- Injections, Intraperitoneal
- Kidney Tubules -- cytology
- L-Lactate Dehydrogenase -- genetics
- Male
- Membrane Potential, Mitochondrial -- drug effects
- Rats
- Rats, Sprague-Dawley
- Reactive Oxygen Species -- agonists
- Tumor Suppressor Protein p53 -- agonists
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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