Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation.
Choi, Yong-Min
Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation. [electronic resource] - PloS one 2015 - e0135083 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0135083 doi
Acetylcysteine--pharmacology
Animals
Antineoplastic Agents--toxicity
Apoptosis--drug effects
Cell Line
Cell Proliferation--drug effects
Cisplatin--toxicity
Citric Acid Cycle--drug effects
Dose-Response Relationship, Drug
Epithelial Cells--cytology
Gene Expression Regulation
Glycolysis--drug effects
Humans
Injections, Intraperitoneal
Kidney Tubules--cytology
L-Lactate Dehydrogenase--genetics
Male
Membrane Potential, Mitochondrial--drug effects
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species--agonists
Tumor Suppressor Protein p53--agonists
Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation. [electronic resource] - PloS one 2015 - e0135083 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0135083 doi
Acetylcysteine--pharmacology
Animals
Antineoplastic Agents--toxicity
Apoptosis--drug effects
Cell Line
Cell Proliferation--drug effects
Cisplatin--toxicity
Citric Acid Cycle--drug effects
Dose-Response Relationship, Drug
Epithelial Cells--cytology
Gene Expression Regulation
Glycolysis--drug effects
Humans
Injections, Intraperitoneal
Kidney Tubules--cytology
L-Lactate Dehydrogenase--genetics
Male
Membrane Potential, Mitochondrial--drug effects
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species--agonists
Tumor Suppressor Protein p53--agonists