Isoniazid prevents Nrf2 translocation by inhibiting ERK1 phosphorylation and induces oxidative stress and apoptosis. [electronic resource]
Producer: 20160902Description: 80-92 p. digitalISSN:- 2213-2317
- Antitubercular Agents -- pharmacology
- Apoptosis -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Gene Expression Profiling
- Gene Expression Regulation
- Heat-Shock Proteins -- genetics
- Hepatocytes
- Humans
- Isoniazid -- pharmacology
- Metabolic Networks and Pathways -- drug effects
- Mitogen-Activated Protein Kinase 3 -- genetics
- NF-E2-Related Factor 2 -- antagonists & inhibitors
- Oxidative Stress -- drug effects
- Phosphorylation -- drug effects
- Protein Transport
- RNA, Messenger -- genetics
- Reactive Oxygen Species -- agonists
- Signal Transduction
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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