Isoniazid prevents Nrf2 translocation by inhibiting ERK1 phosphorylation and induces oxidative stress and apoptosis.

Verma, Ajeet Kumar

Isoniazid prevents Nrf2 translocation by inhibiting ERK1 phosphorylation and induces oxidative stress and apoptosis. [electronic resource] - Redox biology Dec 2015 - 80-92 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2213-2317

10.1016/j.redox.2015.06.020 doi


Antitubercular Agents--pharmacology
Apoptosis--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Gene Expression Profiling
Gene Expression Regulation
Heat-Shock Proteins--genetics
Hepatocytes
Humans
Isoniazid--pharmacology
Metabolic Networks and Pathways--drug effects
Mitogen-Activated Protein Kinase 3--genetics
NF-E2-Related Factor 2--antagonists & inhibitors
Oxidative Stress--drug effects
Phosphorylation--drug effects
Protein Transport
RNA, Messenger--genetics
Reactive Oxygen Species--agonists
Signal Transduction