Rapamycin, a mTOR inhibitor, induced growth inhibition in retinoblastoma Y79 cell via down-regulation of Bmi-1. [electronic resource]
Producer: 20160418Description: 5182-8 p. digitalISSN:- 1936-2625
- Antineoplastic Agents -- pharmacology
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cyclin E -- metabolism
- Dose-Response Relationship, Drug
- Down-Regulation
- G1 Phase Cell Cycle Checkpoints -- drug effects
- Gene Expression Regulation, Neoplastic
- Humans
- Inhibitory Concentration 50
- Oncogene Proteins -- metabolism
- Phosphorylation
- Polycomb Repressive Complex 1 -- genetics
- Protein Kinase Inhibitors -- pharmacology
- RNA Interference
- RNA, Messenger -- metabolism
- Retinal Neoplasms -- drug therapy
- Retinoblastoma -- drug therapy
- Signal Transduction -- drug effects
- Sirolimus -- pharmacology
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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