Rapamycin, a mTOR inhibitor, induced growth inhibition in retinoblastoma Y79 cell via down-regulation of Bmi-1.

Wang, Yan-Dong

Rapamycin, a mTOR inhibitor, induced growth inhibition in retinoblastoma Y79 cell via down-regulation of Bmi-1. [electronic resource] - International journal of clinical and experimental pathology 2015 - 5182-8 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1936-2625


Antineoplastic Agents--pharmacology
Cell Line, Tumor
Cell Proliferation--drug effects
Cyclin E--metabolism
Dose-Response Relationship, Drug
Down-Regulation
G1 Phase Cell Cycle Checkpoints--drug effects
Gene Expression Regulation, Neoplastic
Humans
Inhibitory Concentration 50
Oncogene Proteins--metabolism
Phosphorylation
Polycomb Repressive Complex 1--genetics
Protein Kinase Inhibitors--pharmacology
RNA Interference
RNA, Messenger--metabolism
Retinal Neoplasms--drug therapy
Retinoblastoma--drug therapy
Signal Transduction--drug effects
Sirolimus--pharmacology
TOR Serine-Threonine Kinases--antagonists & inhibitors
Transfection