Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors. (Record no. 25081152)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01895 a2200529 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250517042620.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201511s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1520-4804 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1021/acs.jmedchem.5b00810 |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Holzer, Philipp |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20151116 |
| 245 00 - TITLE STATEMENT | |
| Title | Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Journal of medicinal chemistry |
| Date of publication, distribution, etc. | Aug 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 6348-58 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Antineoplastic Agents |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cell Line, Tumor |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Clinical Trials, Phase I as Topic |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drug Discovery |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Humans |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Isoquinolines |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Piperazines |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Proto-Oncogene Proteins c-mdm2 |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Rats |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Structure-Activity Relationship |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Tumor Suppressor Protein p53 |
| General subdivision | genetics |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Xenograft Model Antitumor Assays |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Masuya, Keiichi |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Furet, Pascal |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kallen, Joerg |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Valat-Stachyra, Therese |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ferretti, Stéphane |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Berghausen, Joerg |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bouisset-Leonard, Michèle |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Buschmann, Nicole |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pissot-Soldermann, Carole |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rynn, Caroline |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ruetz, Stephan |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Stutz, Stefan |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chène, Patrick |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jeay, Sébastien |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gessier, Francois |
| 773 0# - HOST ITEM ENTRY | |
| Title | Journal of medicinal chemistry |
| Related parts | vol. 58 |
| -- | no. 16 |
| -- | p. 6348-58 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1021/acs.jmedchem.5b00810">https://doi.org/10.1021/acs.jmedchem.5b00810</a> |
| Public note | Available from publisher's website |
No items available.