Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors. [electronic resource]
Producer: 20150928Description: 786-94 p. digitalISSN:- 1546-170X
- Adipogenesis -- drug effects
- Animals
- Apoptosis -- drug effects
- Cell Count
- Cell Survival -- drug effects
- Chronic Disease
- Collagen -- metabolism
- Elapid Venoms
- Female
- Fibrosis
- Flow Cytometry
- Macrophages -- cytology
- Male
- Mice, Inbred C57BL
- Mice, Inbred mdx
- Monocytes -- cytology
- Muscle, Skeletal -- drug effects
- Muscular Diseases -- drug therapy
- Pyrimidines -- therapeutic use
- RNA, Messenger -- genetics
- Receptors, CCR2 -- deficiency
- Regeneration -- drug effects
- Signal Transduction -- drug effects
- Stem Cells -- cytology
- Transforming Growth Factor beta1 -- metabolism
- Tumor Necrosis Factor-alpha -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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