Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors.

Lemos, Dario R

Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors. [electronic resource] - Nature medicine Jul 2015 - 786-94 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1546-170X

10.1038/nm.3869 doi


Adipogenesis--drug effects
Animals
Apoptosis--drug effects
Cell Count
Cell Survival--drug effects
Chronic Disease
Collagen--metabolism
Elapid Venoms
Female
Fibrosis
Flow Cytometry
Macrophages--cytology
Male
Mice, Inbred C57BL
Mice, Inbred mdx
Monocytes--cytology
Muscle, Skeletal--drug effects
Muscular Diseases--drug therapy
Pyrimidines--therapeutic use
RNA, Messenger--genetics
Receptors, CCR2--deficiency
Regeneration--drug effects
Signal Transduction--drug effects
Stem Cells--cytology
Transforming Growth Factor beta1--metabolism
Tumor Necrosis Factor-alpha--pharmacology